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Biomedical Chromatography

Biomedical Chromatography

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Development of a HPLC method for determination of four UV filters in sunscreen and its application to skin penetration studies

Published:17 June 2017 DOI: 10.1002/bmc.4029 PMID: 28623841
Carla Souza, Patrícia M.B.G. Maia Campos

Abstract

This study describes the development, validation and application of a high-performance liquid chromatography (HPLC) method for the simultaneous determination of the in vitro skin penetration profile of four UV filters on porcine skin. Experiments were carried out on a gel-cream formulation containing the following UV filters: diethylamino hydroxybenzoyl hexyl benzoate (DHHB), bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) and ethylhexyl triazone (EHT). The HPLC method demonstrated suitable selectivity, linearity (10.0–50.0?μg/mL), precision, accuracy and recovery from porcine skin and sunscreen formulation. The in vitro skin penetration profile was evaluated using Franz vertical diffusion cells for 24?h after application on porcine ear skin. None of the UV filters penetrated the porcine skin. Most of them stayed on the skin surface (>90%) and only BEMT, EHT and DHHB reached the dermis plus epidermis layer. These results are in agreement with previous results in the literature. Therefore, the analytical method was useful to evaluate the in vitro skin penetration of the UV filters and may help the development of safer and effective sunscreen products.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Bisoctrizole 103597-45-1 C41H50N6O2 401 suppliers $15.00-$2509.19
Ethylhexyl Triazone 88122-99-0 C48H66N6O6 348 suppliers $9.00-$1394.66
Bemotrizinol 187393-00-6 C38H49N3O5 331 suppliers $50.00-$667.00
Diethylamino hydroxybenzoyl hexyl benzoate 302776-68-7 C24H31NO4 296 suppliers $11.00-$650.00
Hexyl benzoate 6789-88-4 C13H18O2 173 suppliers $8.00-$727.00
DIETHYLAMINOHYDROXYBENZOYL HEXYL BENZOATE C24H31NO4 3 suppliers Inquiry

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