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ChemicalBook >> journal list >> Evidence-based Complementary and Alternative Medicine >>article

Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.

Published:1 January 2015 DOI: 10.1155/2015/919616 PMID: 26246843
Zhong-Rong Zhang, Wing Nang Leung, Ho Yee Cheung, Chun Wai Chan

Abstract

This paper reviews the latest understanding of biological and pharmacological properties of osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one), a natural product found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. In vitro and in vivo experimental results have revealed that osthole demonstrates multiple pharmacological actions including neuroprotective, osteogenic, immunomodulatory, anticancer, hepatoprotective, cardiovascular protective, and antimicrobial activities. In addition, pharmacokinetic studies showed osthole uptake and utilization are fast and efficient in body. Moreover, the mechanisms of multiple pharmacological activities of osthole are very likely related to the modulatory effect on cyclic adenosine monophosphate (cAMP) and cyclic adenosine monophosphate (cGMP) level, though some mechanisms remain unclear. This review aims to summarize the pharmacological properties of osthole and give an overview of the underlying mechanisms, which showcase its potential as a multitarget alternative medicine.

Substances (2)

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Procduct Name CAS Molecular Formula Supplier Price
Osthole 484-12-8 C15H16O3 488 suppliers $7.00-$2021.25
Adenosine 3',5'-Cyclic Monophosphate (15 mg) 2096332-27-1 1 suppliers Inquiry

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