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European journal of pharmacology

European journal of pharmacology

IF: 4.2
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Cisplatin in cancer therapy: Molecular mechanisms of action

Published:5 October 2014 DOI: 10.1016/j.ejphar.2014.07.025 PMID: 25058905
Shaloam Dasari, Paul Bernard Tchounwou

Abstract

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinomas, germ cell tumors, lymphomas, and sarcomas. Its mode of action has been linked to its ability to crosslink with the purine bases on the DNA; interfering with DNA repair mechanisms, causing DNA damage, and subsequently inducing apoptosis in cancer cells. However, because of drug resistance and numerous undesirable side effects such as severe kidney problems, allergic reactions, decrease immunity to infections, gastrointestinal disorders, hemorrhage, and hearing loss especially in younger patients, other platinum-containing anti-cancer drugs such as carboplatin, oxaliplatin and others, have also been used. Furthermore, combination therapies of cisplatin with other drugs have been highly considered to overcome drug-resistance and reduce toxicity. This comprehensive review highlights the physicochemical properties of cisplatin and related platinum-based drugs, and discusses its uses (either alone or in combination with other drugs) for the treatment of various human cancers. A special attention is paid to its molecular mechanisms of action, and its undesirable side effects.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Cisplatin 15663-27-1 Cl2H6N2Pt 768 suppliers $17.00-$6890.00
Carboplatin 41575-94-4 C6H12N2O4Pt 648 suppliers $33.00-$3650.00
Oxaliplatin 63121-00-6 C8H12N2O4Pt 170 suppliers Inquiry
trans-Dichlorodiamineplatinum(II) 14913-33-8 Cl2H4N2Pt 148 suppliers $28.00-$2200.00

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