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Colloids and Surfaces B: Biointerfaces

Colloids and Surfaces B: Biointerfaces

IF: 5.4
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Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: In vivo

Published:1 March 2006 DOI: 10.1016/j.colsurfb.2006.01.007 PMID: 16497490
Mohammad Changez , Jagdish Chander , Amit Kumar Dinda

Abstract

In vivo transdermal permeation of tetracaine hydrochloride encapsulated in lecithin water-in-oil and oil-in-water microemulsion was studied. The effect of the composition of the lecithin microemulsion on analgesic response of tetracaine hydrochloride was evaluated on Wistar rats by tail flick method. To find out the toxicity of lecithin/n-propanol/isopropyl myristate/water/tetracaine hydrochloride microemulsion histopathological and irritation response were measured in Swiss mice. Time course studies were also conducted for the biochemical response of microemulsion by measuring catalase, glutathione and lipid peroxidation levels of the treated mice skin. The analgesic response was found to be dependent on the drug concentration and composition of the systems. The histopathological, irritation and biochemical findings reveal that lecithin/n-propanol/isopropyl myristate/water/tetracaine hydrochloride microemulsion is a safe carrier for transdermal drug delivery systems. Confocal laser scanning microscopy observation indicated that sweat gland and hair follicle also provided the path for transdermal permeation of lecithin/n-propanol/isopropyl myristate/water microemulsion.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
1-Propanol 71-23-8 C3H8O 810 suppliers $12.00-$10832.70
Isopropyl myristate 110-27-0 C17H34O2 773 suppliers $5.00-$2000.00
Lecithin 8002-43-5 C42H80NO8P 736 suppliers $19.04-$1990.00
Tetracaine hydrochloride 136-47-0 C15H25ClN2O2 625 suppliers $25.00-$2055.90
Water 7732-18-5 H2O 527 suppliers $13.50-$6397.55

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