成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> Journal of Pharmacology & Pharmacotherapeutics >>article

Journal of Pharmacology & Pharmacotherapeutics

IF: 0.4
Download PDF

The safety of ketoprofen in different ages.

Published:1 December 2013 DOI: 10.4103/0976-500X.120967 PMID: 24347993
Claudia Carbone, Pierandrea Rende, Pasquale Comberiati, Domenico Carnovale, Maria Mammì, Giovambattista De Sarro

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID), which acts by blocking cyclooxygenase (COX 1 and 2), an enzyme involved in the production of prostaglandins, messengers in the development of inflammation. All NSAIDs reduce signs of inflammation by blocking this enzyme and therefore prostaglandin production. In Calabria, 3.69% of adverse drug reactions (ADRs) reported in the National Network of Pharmacovigilance concerns the use of ketoprofen; only in one case in which the patient was under the age of 12 years, hospitalization was required for severe episode of pancreatitis. In Italy, Ketoprofen is the 6(th) drug for ADRs incidence (560 ADRs in the year 2012, of which, 31% are severe). Despite the high rate of spontaneous reporting, it must be considered that ketoprofen is one of the most used NSAIDs; therefore, as it happens for other commonly used drugs (eg, amoxicillin), the total number of ADRs should be related to the therapeutic use. However, it remains the problem of fragile patients (eg, children) and the safety of the drug in different ages. This paper presents a retrospective study on 2012 ADRs reviewing literature on the safety of ketoprofen in the elderly, children, and during pregnancy.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Ketoprofen 22071-15-4 C16H14O3 750 suppliers $5.00-$3465.00
Amoxicillin 26787-78-0 C16H19N3O5S 644 suppliers $5.00-$957.10

Similar articles

IF:0

Safety of ketoprofen in the elderly: a prospective study on 20,000 patients.

Scandinavian journal of rheumatology. Supplement X Le Loet,etc Published: 1 January 1989
IF:0

Ketoprofen

Reactions Weekly Published: 1 January 2022
IF:6.8

Mechanism of Photoinduced Decomposition of Ketoprofen

Journal of Medicinal Chemistry Klefah A. K. Musa, Jon M. Matxain,etc Published: 21 March 2007