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Current medicinal chemistry

Current medicinal chemistry

IF: 3.5
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Review camptothecin: current perspectives.

Published:1 January 2006 DOI: 10.2174/092986706777585004 PMID: 16842195
Qing-Yong Li, Yuan-Gang Zu, Rong-Zhen Shi, Li-Ping Yao

Abstract

The review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor agent that targets topoisomerase I. Thousands of CPT derivatives have been synthesized. Two of them, Topotecan and Irinotecan, are commercially approved for use in clinic as antitumor agents while more are still in clinic trials. This review summarizes the current status of the modern synthetic approaches to CPT, the mechanism of action of CPT, the structure-activity relationship(SAR), a number of novel CPT analogs and their biologic activity. There is a systematic evaluation of A-, B- and E-ring- modified camptothecins reported recently.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
(+)-Camptothecin 7689-03-4 C20H16N2O4 656 suppliers $18.00-$1900.44
Irinotecan 97682-44-5 C33H38N4O6 417 suppliers $29.00-$1400.00
Topotecan 123948-87-8 C23H23N3O5 364 suppliers $41.00-$1657.00

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