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Journal of Pharmacology and Experimental Therapeutics

Journal of Pharmacology and Experimental Therapeutics

IF: 3.1
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Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate.

Published:1 June 2005 DOI: 10.1124/jpet.104.081893 PMID: 15734899
Robert P Hanzlik, Stephen C Fowler, Daniel H Fisher

Abstract

Calcium is an essential nutrient required in substantial amounts, but many diets are deficient in calcium making supplementation necessary or desirable. The objective of this study was to compare the oral bioavailability of calcium from calcium formate, a new experimental dietary calcium supplement, to that of calcium citrate and calcium carbonate. In a four-way crossover study, either a placebo or 1200 mg of calcium as calcium carbonate, calcium citrate, or calcium formate were administered orally to 14 healthy adult female volunteers who had fasted overnight. After calcium carbonate, the maximum rise in serum calcium ( approximately 4%) and the fall in serum intact parathyroid hormone 1-84 (iPTH) (approximately 20-40%) did not differ significantly from placebo. After calcium citrate, the changes were modestly but significantly (p < 0.05) greater, but only at 135 to 270 min after ingestion. In contrast, within 60 min after calcium formate serum calcium rose by approximately 15% and serum iPTH fell by 70%. The mean increment in area under the plasma concentration-time curve (0-270 min) for serum calcium after calcium formate (378 mg . min/dl) was double that for calcium citrate (178 mg . min/dl; p < 0.01), whereas the latter was only modestly greater than either placebo (107; p < 0.05) or calcium carbonate (91; p < 0.05). In this study, calcium formate was clearly superior to both calcium carbonate and calcium citrate in ability to deliver calcium to the bloodstream after oral administration. Calcium formate may offer significant advantages as a dietary calcium supplement.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Calcium carbonate 471-34-1 CCaO3 881 suppliers $10.00-$12730.00
Calcium formate 544-17-2 C2H2CaO4 519 suppliers $14.00-$400.00
Calcium citrate 813-94-5 C12H10Ca3O14 325 suppliers Inquiry
Calcium 7440-70-2 Ca 174 suppliers $17.00-$4501.73
Calcium citrate 7693-13-2 C12H10Ca3O14 138 suppliers Inquiry
CALCIUM 14452-75-6 Ca 16 suppliers Inquiry
calcium 14092-94-5 Ca 6 suppliers Inquiry
Calcium Formate 1312710-55-6 C2H2CaO4 1 suppliers Inquiry

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