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Food and Chemical Toxicology

Food and Chemical Toxicology

IF: 3.89
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Fragrance material review on benzyl acetate

Published:1 September 2012 DOI: 10.1016/j.fct.2012.02.057 PMID: 22387848
D. McGinty, D. Vitale, C.S. Letizia, A.M. Api

Abstract

A toxicologic and dermatologic review of benzyl acetate when used as a fragrance ingredient is presented. Benzyl acetate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1–4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for benzyl acetate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, toxicokinetics, repeated dose, reproductive toxicity, genotoxicity, or carcinogenicity data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Refer Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.

Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Hanifin, J.H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2012. A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients. http://dx.doi.org/10.1016/j.fct2012.02.091.

Substances (9)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Benzyl acetate 140-11-4 C9H10O2 729 suppliers $6.00-$1188.00
Butyric Acid 107-92-6 C4H8O2 627 suppliers $9.00-$1284.77
Propanoic acid,2-methyl-, 5-methyl-2-(1-methylethyl)phenyl ester 5451-67-2 C14H20O2 12 suppliers Inquiry
(2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER 6628-34-8 C13H13NO3 9 suppliers $29.80-$1005.43
Carcinogenicity (mice) 2 suppliers Inquiry
Genotoxicity 2 suppliers Inquiry
Drug Toxicokinetics 2 suppliers Inquiry
Preclinical evaluation of reproductive toxicity 2 suppliers Inquiry
Carbonate 552-93-2 C21H26O3 1 suppliers Inquiry

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