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Journal of Colloid and Interface Science

Journal of Colloid and Interface Science

IF: 9.4
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Novel hollow ultrasound-triggered ZnFe2O4-Bi2MoO6 S-scheme heterojunction for efficient ferroptosis-based tumor therapy

Published:10 December 2024 DOI: 10.1016/j.jcis.2024.12.063 PMID: 39673926
Wenting Li,?Zhuoran Yang,?Chunyu Yang,?Wei Guo

Abstract

This study addresses the challenge of enhancing ferroptosis efficacy for tumor therapy, particularly the limited therapeutic efficiency of current inducers due to tumor microenvironment constraints. Herein, we developed a hollow ultrasound-triggered ZnFe2O4-Bi2MoO6 (ZB) S-scheme heterojunction loaded with artesunate (ART) to overcome these limitations. The ZB heterojunction with a particle size of ~250?nm efficiently separates electron-hole pairs under ultrasound (US), promoting the generation of reactive oxygen species (ROS). The photodynamic effect of ZB further boosts ROS production, while ART, controlled-released by phase change materials under laser/US stimulation, enhances ROS production via Fe2+-mediated decomposition. This triple-enhanced strategy accumulates lipid peroxidation (LPO), significantly improving ferroptosis effects with a tumor suppression rate of 94.3?%. Moreover, ZB enables multimodal imaging and stimulates antitumor immunity, demonstrating its potential as a diagnostic and therapeutic agent. Our findings demonstrate the potential of this ZB@ART system in advancing ferroptosis-based tumor therapies, inspiring future designs of efficient ferroptosis inducers.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Lauric acid 143-07-7 C12H24O2 845 suppliers $5.00-$4265.73
Urea 57-13-6 CH4N2O 776 suppliers $5.00-$9263.00
Tetramethylbenzidine 54827-17-7 C16H20N2 564 suppliers $6.00-$4480.00
Propidium iodide 25535-16-4 C27H34IN4+ 297 suppliers $29.00-$1780.00
2′,7′-Dichlorodihydrofluorescein Diacetate 4091-99-0 C24H16Cl2O7 177 suppliers $33.00-$1947.00

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