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Journal of Colloid and Interface Science

Journal of Colloid and Interface Science

IF: 9.4
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Photonic hydrogels combining the slow photon effect and NO gas therapy for synergetic enhanced photodynamic antibacterial therapy

Published:6 December 2024 DOI: 10.1016/j.jcis.2024.12.018 PMID: 39671952
Hui Wang,?Duohang Bi,?Bowen Yu,?Qiang Chen,?Shuo Du,?Ge Xie,?Jintao Zhu,?Lianbin Zhang

Abstract

Photodynamic therapy (PDT) offers potential for combating bacterial infections through the generation of reactive oxygen species (ROS). However, the antibacterial efficiency of PDT is largely impeded by the limited photon absorption of photosensitizers and the short diffusion length and lifespan of ROS. Herein, we present a light-harvesting platform based on l-arginine-modified photonic hydrogels loaded with new indocyanine green (PG@Arg/IR820) for synergizing the slow photon effect with NO gas therapy to enhance PDT antibacterial efficiency. Upon near-infrared (NIR) light irradiation, PG@Arg/IR820 can maximize the utilization of photons via the slow photon effect to generate sufficient ROS, which not only acts as the primary bactericidal agent in PDT but also triggers l-arginine to generate NO. NO exhibits a long diffusion distance and lifespan and can freely diffuse to inhibit distant bacterial growth, demonstrating a vital complementary advantage in bacterial inactivation by ROS. The synergistic effect of the slow photon effect combined with NO gas therapy allows PG@Arg/IR820 to intensify bacterial destruction and enhance PDT antibacterial efficiency. This antibacterial system sheds light on an advisable design principle for efficient antibacterial activities in photodynamic inactivation.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Acetic acid 64-19-7 C2H4O2 1631 suppliers $10.00-$8459.00
L(+)-Arginine 74-79-3 C6H14N4O2 1236 suppliers $5.00-$6815.00
Chitosan 9012-76-4 C6H11NO4X2 861 suppliers $14.00-$1125.56
Ethanol 64-17-5 C2H6O 807 suppliers $10.00-$17310.00
Glutaraldehyde 111-30-8 C5H8O2 560 suppliers $13.50-$1930.00
Tetraethyl orthosilicate 78-10-4 C8H20O4Si 476 suppliers $12.00-$1350.00

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