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Analytical Chemistry

Analytical Chemistry

IF: 6.7
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Autonomous Sweating Wearable Platform for Bilirubin Sensing Based on Thermal Stimulation

Published:12 December 2024 DOI: 10.1021/acs.analchem.4c04592
Zhongzeng Zhou, Jing Wang, Tailin Xu, Xueji Zhang

Abstract

Bilirubin (BR), with diverse physiological functions and health implications, is a vital biomarker related to liver diseases such as jaundice and hepatitis. It is generally tested by blood. Sweat wearable devices provide a noninvasive way to monitor BR but face challenges in stability and selectivity, and acquiring sufficient sweat is difficult for sedentary individuals. This study introduces an innovative autonomous sweating wearable platform for noninvasive monitoring of bilirubin levels. The platform incorporates an autonomous heating film for controlled sweat extraction, a skin-interfaced microfluidic system for efficient sweat sampling, and a flexible electrode for accurate BR sensing. The utilization of MXene/MWCNT in the platform enables precise and sensitive electrochemical detection of trace-level BR directly on the skin. The integration of a laser-engraved flexible heating film and a microfluidic system allows for controlled and reliable sweat sampling, enabling easy biomarker detection at rest. The platform demonstrates effective sweat sampling and accurate BR detection, showcasing its potential for noninvasive health monitoring applications. Its design and functionality offer a promising solution for continuous and convenient monitoring of BR levels, providing a novel approach to sweat biomarker analysis.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ascorbic Acid 50-81-7 C6H8O6 1625 suppliers $6.00-$2170.00
Glycine 56-40-6 C2H5NO2 1440 suppliers $5.00-$37817.00
Sodium chloride 7647-14-5 ClNa 1215 suppliers $5.00-$6678.62
N,N-Dimethylformamide 68-12-2 C3H7NO 1214 suppliers $11.20-$12200.00
D(+)-Glucose 50-99-7 C6H12O6 1113 suppliers $6.00-$26950.00
L-Tryptophan 73-22-3 C11H12N2O2 1111 suppliers $5.00-$8386.00
DL-Serine 302-84-1 C3H7NO3 639 suppliers $5.00-$1456.00
DL-Phenylalanine 150-30-1 C9H11NO2 639 suppliers $10.00-$1500.00
Bilirubin 635-65-4 C33H36N4O6 583 suppliers $30.00-$2637.00
DL-Tyrosine 556-03-6 C9H11NO3 396 suppliers $10.00-$1356.00

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