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Cell stem cell

Cell stem cell

IF: 19.8
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Maternal gut microbiota influence stem cell function in offspring

Published:11 December 2024 DOI: 10.1016/j.stem.2024.10.003
Haiyue Dang, Panpan Feng, Shuning Zhang, Lihua Peng, Shuli Xing, Yuchen Li, Xiang Wen, Liqiang Zhou, Shyamal Goswami, Mingbing Xiao, Nick Barker, Philippe Sansonetti, Parag Kundu

Abstract

The maternal microbiome influences child health. However, its impact on a given offspring’s stem cells, which regulate development, remains poorly understood. To investigate the role of the maternal microbiome in conditioning the offspring’s stem cells, we manipulated maternal microbiota using Akkermansia muciniphila. Different maternal microbiomes had distinct effects on proliferation and differentiation of neuronal and intestinal stem cells in the offspring, influencing their developmental trajectory, physiology, and long-term health. Transplantation of altered maternal microbiota into germ-free mice transmitted these stem cell phenotypes to the recipients’ offspring. The progeny of germ-free mice selectively colonized with Akkermansia did not display these stem cell traits, emphasizing the importance of microbiome diversity. Metabolically more active maternal microbiomes enriched the levels of circulating short-chain fatty acids (SCFAs) and amino acids, leaving distinct transcriptomic imprints on the mTOR pathway of offsprings’ stem cells. Blocking mTOR signaling during pregnancy eliminated the maternal-microbiome-mediated effects on stem cells. These results suggest a fundamental role of the maternal microbiome in programming offsprings’ stem cells and represent a promising target for interventions.

Substances (14)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Potassium chloride 7447-40-7 KCl 1315 suppliers $6.00-$11230.00
Sodium chloride 7647-14-5 ClNa 1218 suppliers $5.00-$6678.62
D(+)-Glucose 50-99-7 C6H12O6 1121 suppliers $6.00-$26950.00
L-Cysteine 52-90-4 C3H7NO2S 1091 suppliers $6.00-$15643.00
Potassium Phosphate Monobasic 7778-77-0 H2KO4P 937 suppliers $9.00-$7640.00
Sorbitol 50-70-4 C6H14O6 833 suppliers $5.00-$2150.00
L-Threonine 72-19-5 C4H9NO3 816 suppliers $4.77-$23730.00
N-Acetyl-D-Glucosamine 7512-17-6 C8H15NO6 726 suppliers $5.00-$1688.96
Sucrose 57-50-1 C12H22O11 669 suppliers $5.00-$8025.00
Sodium Phosphate, Dibasic 7558-79-4 Na2HPO4 662 suppliers $9.00-$4630.00

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