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Cellular signalling

Cellular signalling

IF: 4.4
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SSBP1 positively regulates RRM2, affecting epithelial mesenchymal transition and cell cycle arrest in human lung adenocarcinoma cells

Published:4 December 2024 DOI: 10.1016/j.cellsig.2024.111552 PMID: 39643024
Xingyu Yang,?Bingfeng Ma,?Yafeng Liu,?Jiawei Zhou,?Jianqiang Guo,?Yuanyuan Peng,?Ying Bai,?Jing Wu,?Dong Hu

Abstract

Progression of lung adenocarcinoma (LUAD) is frequently associated with alterations in epithelial-mesenchymal transition (EMT) and cell cycle. Our study analyzed the Cancer Genome Atlas (TCGA) database and identified a positive correlation between high expression of SSBP1 in LUAD tumor tissues and poor prognosis (p?

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