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ACS Chemical Neuroscience

ACS Chemical Neuroscience

IF: 4.09
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Novel Perspective on Sevoflurane-Induced Cognitive Dysfunction: Implications of Neuronal SIRPα and Microglial Synaptic Remodeling

Published:7 December 2024 DOI: 10.1021/acschemneuro.4c00485 PMID: 39644326
Wei Du,?Xiaomin Zhang,?Songze Li,?Xin Xie

Abstract

This study aims to investigate the role of neuronal SIRPα and microglial synaptic remodeling in sevoflurane-induced cognitive dysfunction in newborn mice. Newborn mice were exposed to sevoflurane, followed by behavioral assessments and single-cell transcriptome sequencing of cortical cells. Lentivirus-mediated overexpression of neuronal SIRPα and assessment of the microglial morphology and synaptic function were conducted. Sevoflurane exposure resulted in social cognitive impairments without affecting motor coordination. Transcriptomic analysis revealed no significant changes in cortical microglial cells or neurons. However, sevoflurane inhibited nonsynaptic synapse modification by microglia. Overexpression of neuronal SIRPα enhanced microglial function, promoted neuron development, and ameliorated cognitive impairments. SCENIC analysis identified a correlation between IRF8 and SIRPα expression. This study sheds light on the involvement of neuronal SIRPα and microglial synaptic remodeling in sevoflurane-induced cognitive dysfunction. Understanding these mechanisms offers new avenues for exploring cognitive impairment pathways and potential therapeutic targets.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Potassium chloride 7447-40-7 KCl 1310 suppliers $6.00-$11230.00
Sodium chloride 7647-14-5 ClNa 1214 suppliers $5.00-$6678.62
Calcium chloride 10043-52-4 CaCl2 942 suppliers $5.00-$26371.00
Potassium hydroxide 1310-58-3 KOH 747 suppliers $10.00-$7430.00
HEPES 7365-45-9 C8H18N2O4S 741 suppliers $6.00-$17250.00
Ethylenebis(oxyethylenenitrilo)tetraacetic acid 67-42-5 C14H24N2O10 442 suppliers $13.43-$4210.00
CNQX 115066-14-3 C9H4N4O4 120 suppliers $50.00-$1140.00
PICROTOXININ 17617-45-7 C15H16O6 68 suppliers $50.00-$344.00