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Advanced Healthcare Materials

Advanced Healthcare Materials

IF: 10
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Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells

Published:28 November 2024 DOI: 10.1002/adhm.202403490 PMID: 39610189
Qiming Pang, Zhuolin Chen, Jingdi Zhan, Jiacheng Liu, Junyan Liu, Weikang Zhao, Wei Huang, Lili Dong

Abstract

Osteoarthritis (OA) represents a common degenerative joint disorder marked by progressive cartilage degradation, necessitating innovative therapeutic approaches beyond symptom management. Here, this study introduces a novel strategy leveraging the regenerative capabilities of mesenchymal stem cells (MSCs) by utilizing a bioactive extracellular matrix (ECM) derived from IFN-γ-stimulated MSCs, encapsulated within aldehyde- and methacrylic anhydride-modified hyaluronic acid hydrogel microspheres (AH). This engineered scaffold effectively mimics the native cartilage microenvironment, promoting targeted adhesion and retention at damaged sites via spontaneous Schiff base reactions. Notably, the IFN-γ-ECM@AH microspheres facilitate the localized release of key chemokines, such as CXCL12, enhancing endogenous stem cell recruitment, and bioactive factors (e.g., TGF-βI and TGF-β3) to drive chondrogenic differentiation. Additionally, the scaffold possesses binding sites for cellular integrins, further augmenting the regenerative potential of stem cells. Collectively, the approach presents a dual-action mechanism that supports efficient cartilage repair and regeneration, positioning this engineered microenvironment as a promising therapeutic avenue for OA and potentially other degenerative conditions.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Methacrylic anhydride 760-93-0 C8H10O3 364 suppliers $33.60-$182.00
Hydroxyapatite 1306-06-5 Ca5HO13P3 349 suppliers $26.00-$4474.44
Toluidine Blue O 92-31-9 C15H16ClN3S 257 suppliers $16.70-$1570.00
Hyaluronidase 37326-33-3 NULL 194 suppliers $72.90-$1500.00
Collagenase 9001-12-1 C60H100N2 177 suppliers $59.90-$6110.00
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00

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