成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> Thoracic Cancer >>article
Thoracic Cancer

Thoracic Cancer

IF: 2.29
Download PDF

Effect of Transferrin‐Modified Fe3O4 Nanoparticle Targeted Delivery miR‐15a‐5p Combined With Photothermal Therapy on Lung Cancer

Published:27 November 2024 DOI: 10.1111/1759-7714.15497 PMID: 39604129
Xiaoxu Lan, Xiao Wang, Liying Shao, Jiayue An, Simin Rong, Xiancong Yang, Hongfang Sun, Yan Liang, Ranran Wang, Shuyang Xie, Youjie Li

Abstract

Background: Existing studies have shown that transferrin receptor (TfR) is highly expressed on the surface of lung cancer cells, and nanoparticles (NPs) have been widely used as delivery vehicles. The aim of this study was to investigate the effect of the targeted delivery of Fe3O4 NPs modified with transferrin (Tf) compared with photothermal treatment for lung cancer.

Methods: The morphology and properties of Fe3O4 NPs modified with Tf were tested by internal morphological characterization experiments including transmission electron microscopy, particle size meter infrared spectrometer and other experiments. The delivery of materials was investigated by cell proliferation and apoptosis experiments, and western blot experiment was used to detect yes-associated protein 1(YAP1) protein expression changes after delivering miR-15a-5p. In addition, animal models were constructed to further explore the targeting properties of the material.

Results: The results demonstrated that the nanomaterial has good stability and targeting properties. Meanwhile, we also discovered that the miR-15a-5p carried by NPs can inhibit cell growth after its entry to the lung cancer cells. The effect became more evident when the nanomaterials were assisted with laser therapy, as verified by in?vivo and in?vitro experiments. In terms of the related mechanism, miR-15a-5p inhibited YAP1 expression, which affected cell proliferation and apoptosis.

Conclusion: In this study, Fe3O4 NPs modified with Tf delivered miR-15a-5p in combination with photothermal therapy for lung cancer. In future research, the targeted delivery of Tf and the photothermal synergy of nanomaterials will provide a theoretical basis for cancer treatment.

Similar articles

IF:3

A comprehensive review on Brigatinib – A wonder drug for targeted cancer therapy in non-small cell lung cancer

Saudi Pharmaceutical Journal Silky Bedi , Shah A. Khan ,etc Published: 1 September 2018
IF:8.7

Decellularized adipose matrix hydrogel-based in situ delivery of antagomiR150-5p for rat abdominal aortic aneurysm therapy

Materials Today Bio Xin Chen, Shoushuai Wang,etc Published: 20 November 2024
IF:10.7

Antibacterial betaine modified chitosan-based hydrogel with angiogenic property for photothermal enhanced diabetic wound repairing

Carbohydrate Polymers Kaiyue Zhang, Jingjing Zhu,etc Published: 19 November 2024