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The Journal of Organic Chemistry

The Journal of Organic Chemistry

IF: 3.29
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TEMPO-Mediated Dehydrogenative Hydroxyfluoroalkylation of Arylamines with Polyfluorinated Alcohols

Published:23 April 2024 DOI: 10.1021/acs.joc.4c00185
Xiaoyang Gao, Juting Liao, Hengyi Wei, Ye Xu, Ruirui Zhai, Dulin Kong*, Shuojin Wang* and Xun Chen*, 

Abstract

An efficient 2,2,6,6-tetramethylpiperidinooxy (TEMPO)-mediated hydroxyfluoroalkylation of arylamines with polyfluorinated alcohols via a radical-triggered C(sp2)–H/C(sp3)–H dehydrogenative cross-coupling process was developed. This transformation features simple operation, high atom economy, broad substrate compatibility, and excellent regioselectivity, leading to a series of hydroxyfluoroalkylated arylamine derivatives. Importantly, these synthetic products were further used to evaluate the antitumor activity in cancer cell lines by Cell Counting Kit-8 assay and the outcomes indicated that some compounds show a potent antiproliferative effect.

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Procduct Name CAS Molecular Formula Supplier Price
TEMPO 2564-83-2 C9H18NO* 659 suppliers $6.00-$2433.70
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Polyfluorinated alkyl thiol - Inquiry

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