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Current topics in medicinal chemistry

Current topics in medicinal chemistry

IF: 2.89
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Current Fragment-to-lead Approaches Starting from the 7-azaindole: The Pharmacological Versatility of a Privileged Molecular Fragment.

Published:1 January 2023 DOI: 10.2174/1568026623666230718100541 PMID: 37461366
Leandro Marcos Santos, Nelson José Freitas da Silveira

Abstract

Fragment-based drug discovery is one of the most powerful paradigms in the recent context of medicinal chemistry and is being widely practiced by academic and industrial researchers. Currently, azaindoles are among the most exploited molecular fragments in pharmaceutical innovation projects inspired by fragment-to-lead strategies. The 7-azaindole is the most prominent representative within this remarkable family of pyrrolopyridine fragments, as it is present in the chemical structure of several approved antitumor drugs and also of numerous therapeutic candidates. In this paper, a brief overview on existing proofs of concept in the literature will be presented, as well as some recent works that corroborate 7-azaindole as a privileged and pharmacologically versatile molecular fragment.

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Procduct Name CAS Molecular Formula Supplier Price
7-Azaindole 271-63-6 C7H6N2 680 suppliers $9.00-$1800.00

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