鹽酸樂(lè)卡地平概述藥理作用用途MSDS用途與合成方法鹽酸樂(lè)卡地平價(jià)格(試劑級(jí))上下游產(chǎn)品信息專(zhuān)題中文名稱(chēng):鹽酸樂(lè)卡地平中文同義詞:鹽酸樂(lè)卡地平;1,4-二氫-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸2-[(3,3-二苯丙基)甲基氨基]-1,1-二甲基乙基甲酯鹽酸鹽;樂(lè)卡地平雜質(zhì)1;樂(lè)卡地平鹽酸鹽(標(biāo)準(zhǔn)品);再寧平;鹽酸樂(lè)卡地平,≥98%(HPLC);BCL-10重組兔單克隆抗體英文名稱(chēng):Lercanidipinehydrochloride英文同義詞:1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethylmethylesterhydrochloride;LERCANIDIPINEHCL;LERCANIDIPINEHYDROCHLORIDE;1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth;1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethylMethylEsterHydrochloride;3-(1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl)5-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylatehydrochloride;3,5-Pyridinedicarboxylicacid,1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl]5-Methylester,hydrochloride(1:1);LercanidipineImpurity1CAS號(hào):132866-11-6分子式:C36H42ClN3O6分子量:648.19EINECS號(hào):603-682-3相關(guān)類(lèi)別:醫(yī)藥降壓藥;醫(yī)藥中間體;醫(yī)藥原料;中間體;細(xì)胞信號(hào)和神經(jīng)生物學(xué);原料藥;MiscellaneousNaturalProducts;DihydropyridineClassChemicals;Aromatics;Dihydropyridine;Heterocycles;細(xì)胞生物學(xué);API;CardiovascularAPIs;生物活性小分子;對(duì)照品;對(duì)照品-雜質(zhì)對(duì)照品;醫(yī)用原料;Intermediates&FineChemicals;Pharmaceuticals;CalciumChannelModulators;InhibitorsandActivators;Voltage-gatedIonChannelsMol文件:132866-11-6.mol鹽酸樂(lè)卡地平性質(zhì)熔點(diǎn)175-177°C儲(chǔ)存條件2-8°C形態(tài)powder顏色yellowMerck14,5446InChIKeyWMFYOYKPJLRMJI-UHFFFAOYSA-NCAS數(shù)據(jù)庫(kù)132866-11-6(CASDataBaseReference)鹽酸樂(lè)卡地平用途與合成方法概述鹽酸樂(lè)卡地平為第三代二氫吡啶類(lèi)鈣通道阻滯劑，其作用機(jī)制與同類(lèi)藥物相似，即可逆地阻滯血管平滑肌細(xì)胞膜L型鈣通道的鈣離子內(nèi)流，擴(kuò)張外周血管而降低血壓。藥理作用鹽酸樂(lè)卡地平為第三代二氫吡啶類(lèi)鈣通道阻滯劑，其親脂性較高，起效時(shí)間較慢，作用時(shí)間較長(zhǎng)，血漿達(dá)峰時(shí)間為2~3h，具有首過(guò)代謝的飽和性，食物可增加其吸收，吸收后迅速分布、積聚在細(xì)胞膜脂質(zhì)雙層，蛋白結(jié)合率高于98%。鹽酸樂(lè)卡地平主要由CYP3A4代謝，具有廣泛的首過(guò)效應(yīng)，無(wú)活性代謝產(chǎn)物。50%由糞便排出，44%由尿液排出。用途長(zhǎng)效鈣拮抗劑-鹽酸樂(lè)卡地平，其降壓療效肯定，同時(shí)具有腎臟保護(hù)作用，對(duì)血脂也有利。