R,S-Sulforaphane is a synthetic isothiocyanate. R-Sulforaphane is the naturally-occurring isomer, found in broccoli. This compound exhibits antioxidative, neuroprotective, anti-inflammatory, anti-atherosclerotic, neuromodulatory, cardioprotective, anticoagulant, antibiotic, anticancer chemotherapeutic, and chemopreventive activities; research suggests that the R-isomer may be more bioactive than the S-isomer. R,S-Sulforaphane induces activity and expression of phase II enzymes, inhibits the aryl hydrocarbon receptor, and downregulates expression of HDACs and STAT5.
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