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試劑描述：

產品名稱：Filipin III

產品別名：16,20,22,24-Octacosapentenoic acid, 3,5,7,9,11,13,15,26,27-nonahydroxy-2-(1-hydroxyhexyl)-16-methyl-, 27-lactone

CAS號：480-49-9

英文別名：Filipin III

分子量：654.83

分子式：C₃₅H₅₈O₁₁

純度：>90%

外觀：見愛必信官網

保存方法：Store at -20° C

描述：

Filipin III is a pentaene macrolide antibiotic and the predominant isomer of four isomeric polyene macrolides isolated from cultures of S. filipinensis. Due to Filipin III’s ability to fluoresce and bind to cholesterol, the compound has been used to detect cholesterol in membranes through freeze fracture electron microscopy and through decreased fluorescence of Filipin III upon binding. The compound has also been used in tobacco cells and observed to activate ligand-independent signaling responses. Through Filipin III’s cholesterol sequestering activity, the compound was able to disrupt the lipid rafts in both normal and transformed keratinocytes resulting in inhibition of the AKT pathway.

應用：A cholesterol-binding, fluorescing antibiotic

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