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HSP70 Antibody
  • HSP70 Antibody

HSP70 Antibody

價(jià)格 1200
包裝 1EA
最小起訂量 1EA
發(fā)貨地 上海
更新日期 2020-01-17

產(chǎn)品詳情

英文名稱:HSP70 Antibody
保質(zhì)期: 一年保存條件: 低溫
規(guī)格: 20?ul?(2 western blots)CAS號: WB , IHC ,
英文名: HSP70 Antibody供應(yīng)商: 科敏商城
數(shù)量: 大量貨號: HSP70 Antibody
2020-01-17 HSP70 Antibody HSP70 Antibody 1EA/1200RMB 1200

微信關(guān)注 科敏商城 在線客服CST火熱促銷中



品牌:CST,產(chǎn)品名稱:HSP70 Antibody #4872
英文名稱:HSP70 Antibody
Product name:HSP70 Antibody #4872
Isotype:Mouse IgG1
Sensitivity:Endogenous
MW(kDa):70
Applications:WB , IHC ,
Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human HSP70. Antibodies are purified by protein A and peptide affinity chromatography.
Background: HSP70 and HSP90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are induced upon environmental stress (1). Both HSP70 and HSP90 are able to interact with unfolded proteins to prevent irreversible aggregation and catalyze the refolding of their substrates in an ATP- and co-chaperone-dependent manner (1). HSP70 has a broad range of substrates including newly synthesized and denatured proteins, while HSP90 tends to have a more limited subset of substrates, most of which are signaling molecules. HSP70 and HSP90 often function collaboratively in a multi-chaperone system, which requires a minimal set of co-chaperones: HSP40, Hop, and p23 (2,3). The co-chaperones either regulate the intrinsic ATPase activity of the chaperones or recruit chaperones to specific substrates or subcellular compartments (1,4). When the ubiquitin ligase CHIP associates with the HSP70/HSP90 complex as a cofactor, the unfolded substrates are subjected to degradation by the proteasome (4). The biological functions of HSP70/HSP90 extend beyond their chaperone activity. They are essential for the maturation and inactivation of nuclear hormones and other signaling molecules (1,3). They also play a role in vesicle formation and protein trafficking (2).

Entrez-Gene Id

3303

Swiss-Prot Acc.

P0DMV8

Specificity / Sensitivity:

HSP70 Antibody detects endogenous levels of total HSP70 protein (HSP70-Hom, HSP70-1) and HSPC70.

Species Reactivity:

Human, Mouse, Rat, Monkey, Bovine

ApplicationDilutions
Western Blotting1:1000
Immunohistochemistry (Paraffin)1:200
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

科研采購盡在科敏商城

溫馨提示:不可用于臨床治療。
關(guān)鍵字: HSP70 Antibody;試劑

公司簡介

成立日期 2016-03-21 (9年) 注冊資本 500萬人民幣
員工人數(shù) 年?duì)I業(yè)額
主營行業(yè) 經(jīng)營模式
  • 上海振譽(yù)生物科技有限公司
非會員
  • 公司成立:9年
  • 注冊資本:500萬人民幣
  • 企業(yè)類型:董艷民
  • 主營產(chǎn)品:
  • 公司地址:上海市虹梅南路4289號 郵編:
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