背景資料
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
關(guān)鍵字: Anti-SFN Polyclonal Antibody;抗體
北京索萊寶科技有限公司是一家集研發(fā)、生產(chǎn)、銷售、服務(wù)于一體的高科技生物企業(yè)。技術(shù)推廣;技術(shù)轉(zhuǎn)讓;技術(shù)咨詢;技術(shù)服務(wù);生物試劑技術(shù)開發(fā);銷售生物試劑盒、實(shí)驗(yàn)室專用化學(xué)試劑、實(shí)驗(yàn)室專用設(shè)備、辦公用品、化工產(chǎn)品(不含危險(xiǎn)化學(xué)品)、計(jì)算機(jī)軟件及輔助設(shè)備;貨物進(jìn)出口、技術(shù)進(jìn)出口、代理進(jìn)出口;委托加工生產(chǎn)生物制品、生化制品、化工產(chǎn)品(不含危險(xiǎn)化學(xué)品);生產(chǎn)生物試劑盒;批發(fā)第一類醫(yī)療器械、第二類醫(yī)療器械;批發(fā)第三類醫(yī)療器械。