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抗體
ANTI-ATF5 POLYCLONAL ANTIBODY
Anti-ATF5 Polyclonal Antibody
Anti-ATF5 Polyclonal Antibody
價格
¥
1600.00
¥
960.00
包裝
100ul
50ul
最小起訂量
50ul
發(fā)貨地
北京
更新日期
2025-01-24
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產(chǎn)品詳情
中文名稱:
Anti-ATF5 Polyclonal Antibody
英文名稱:
Anti-ATF5 Polyclonal Antibody
Subcellular Locations:
Nucleus
Swiss Prot:
Q9Y2D1
保存:
Store at -20°C. Avoid freeze / thaw cycles.
別名:
ATFX
產(chǎn)品編號:
K107683P
儲存液:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法:
Affinity purification
蛋白分子量:
30kDa
交叉反應(yīng):
Human Mouse Rat
克隆類型:
Polyclonal Antibody
免疫原:
A synthetic peptide of human ATF5
品牌:
Solarbio
宿主:
Rabbit
稀釋比例:
WB 1:1000-1:3000.
亞型:
IgG
應(yīng)用:
WB
英文名稱:
Anti-ATF5 Polyclonal Antibody
2025-01-24
Anti-ATF5 Polyclonal Antibody
Anti-ATF5 Polyclonal Antibody
100ul/1600.00RMB;50ul/960.00RMB
1600.00
背景資料
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
關(guān)鍵字:
Anti-ATF5 Polyclonal Antibody;抗體
公司簡介
北京索萊寶科技有限公司是一家集研發(fā)、生產(chǎn)、銷售、服務(wù)于一體的高科技生物企業(yè)。技術(shù)推廣;技術(shù)轉(zhuǎn)讓;技術(shù)咨詢;技術(shù)服務(wù);生物試劑技術(shù)開發(fā);銷售生物試劑盒、實驗室專用化學(xué)試劑、實驗室專用設(shè)備、辦公用品、化工產(chǎn)品(不含危險化學(xué)品)、計算機軟件及輔助設(shè)備;貨物進出口、技術(shù)進出口、代理進出口;委托加工生產(chǎn)生物制品、生化制品、化工產(chǎn)品(不含危險化學(xué)品);生產(chǎn)生物試劑盒;批發(fā)第一類醫(yī)療器械、第二類醫(yī)療器械;批發(fā)第三類醫(yī)療器械。
成立日期
2004-09-22
(21年)
注冊資本
1000萬元
員工人數(shù)
50-100人
年營業(yè)額
¥ 500萬-1000萬
主營行業(yè)
分析化學(xué),生物化工,化學(xué)試劑,醫(yī)藥原料,儀器耗材
經(jīng)營模式
貿(mào)易,工廠,試劑
北京索萊寶科技有限公司
VIP
9年
公司成立:
21年
注冊資本:
1000萬元
企業(yè)類型:
有限責任公司
主營產(chǎn)品:
tris,甘氨酸,瓊脂粉,潮霉素B,SDS,BSA
公司地址:
聯(lián)東U谷景盛南四街85A三層
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