ProSci Incorporated 於1998年成立于世界生物城之一的美國(guó)加州圣地亞哥市，是世界最早和的細(xì)胞凋亡抗體生產(chǎn)廠家和供應(yīng)商，公司現(xiàn)擁有17000多種單、多克隆抗體，產(chǎn)品涵蓋了細(xì)胞凋亡、信號(hào)轉(zhuǎn)導(dǎo)、免疫、腫瘤、細(xì)胞生物、神經(jīng)生物、傳染病等領(lǐng)域。ProSci公司的抗體大都經(jīng)免疫親和層析純化，經(jīng)過(guò)了嚴(yán)格的驗(yàn)證測(cè)試和質(zhì)量控制，具有高純度、高親和力、特異性強(qiáng)等特點(diǎn)，可用于免疫印跡（Western blot），免疫組織化學(xué)（IHC），免疫細(xì)胞化學(xué)（ICC），酶聯(lián)免疫吸附實(shí)驗(yàn)（ELISA）和細(xì)胞流式分析（FACS）等方面。ProSci的抗體產(chǎn)品已應(yīng)用在1281篇SCI論文中，其中2011年的有228篇，ProSci的經(jīng)銷商和客戶都對(duì)ProSci的產(chǎn)品質(zhì)量和服務(wù)十分滿意，ProSci公司在2003、2007、2010年度都被《Nature》評(píng)為免疫學(xué)試劑推薦品牌，抗體研發(fā)、生產(chǎn)和服務(wù)優(yōu)秀供應(yīng)商。
Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.