Product name
AR Polyclonal Antibody
Isotype
IgG
Form
Lyophilized or Liquid
Tested applications
WB,IHC,ELISA
Species reactivity
Human,Mouse
Host Species
Rabbit
Purity
Affinity purification
?
Immunogen Information:
Immunogen
A synthetic peptide of human AR
Calculated molecular weight
44kDa/67kDa/99kDa
Observed molecular weight?
110kDa
Swiss Prot
P10275
Gene ID (NCBI)
367
Alternative Names
AIS;AR8;DHTR;HUMARA;HYSP1;KD;NR3C4;SBMA;SMAX1;TFM
Application Notes:
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
1:500 - 1:2000
IHC
1:50 - 1:100
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Western blot analysis of extracts of 22RV1 cells, using AR Antibody.
Immunohistochemistry of paraffin-embedded mouse brain using AR antibody.
Background:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.? ?
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Storage:
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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