JANSSEN PHARMACEUTICA N.V., WO2005/54210, A1, (2005) Example A3 a) Preparation of intermediate 5 A mixture of 6-bromo-2-chloro-3-methyl-quinoline (0.044 83 mol) and CH3ONa (0.224 mol) in MeOH (200ml) was stirred at 70°C for 36 hours. The mixture was coo led, poured into ice, EtOAc was added and the mixture was extracted with EtOAc. The organic layer was washed with water, dried (MgSO4), filtered off and evaporated, yielding llg (97percent) of interme diate 5
上海百韌生物科技有限公司
聯(lián)系商家時請?zhí)峒癱hemicalbook,有助于交易順利完成!
上海百韌