Melting Point: 214~215℃ Soubility: Soluble in Chloroform,Methanol,Ethanol,and slightly in water. Appearance: White or milk white powder, oderless. Pharmacology Action: Huperzine A may have cognition-enhancing activity, can maintains acetylcholine levels for healthy cognitive function and promotes enhanced memory and cell to cell communication,it is potentially ward off the devastating effect of the memory-robbing disease Alzheimer's. Dosage:Huperzine A is a highly potent compound with a recommended dose of only 100 to 200 micrograms twice a day for age-related memory loss. We recommend using it only under a doctor's supervision. Safety Issues:Perhaps because it works so specifically, huperzine A appears to have few side effects. However, children, pregnant or nursing women, or those with high blood pressure or severe liver or kidney disease should not take huperzine A except on a doctor's recommendation. We also don't know for sure whether huperzine A interacts adversely with any drugs; however, it seems likely that huperzine might interact with drugs that function in a similar fashion (such as standard drugs for Alzheimer's Disease).
熔點:214~215 ℃ 溶解性:易溶于氯仿,溶于甲醇、乙醇,微溶于水 性狀:白色或奶白色粉末,無味。 藥理作用:本品系由石杉科植物千層塔[Huperzinaserrata(Thumb.)Trev]中提取的一種生物堿,是一強效的膽堿酯酶可逆性抑制劑,其作用特點與新斯的明相似,但作用維持時間比后者為長。動物實驗表明,本品對真性膽堿酯酶具有選擇性的抑制,抑制強度是假性膽堿酯酶的數(shù)千倍;抑制方式為競爭性和非競爭性的混合型抑制,與單純競爭性抑制劑有顯著不同;易通過血腦屏障進入中樞,兼具有中樞及外周治療作用;有效時間長;從胃腸道吸收良好;安全指數(shù)大;穩(wěn)定性好。是一種強效的可逆性AChE抑制劑,能改善老年性記憶功能減退,可顯著提高AD患者的記憶、認知和行為功能,無明顯不良反應,是治療阿耳茨海默病的一個有前景的藥物。 適應癥:本品適用于良性記憶障礙、腦血管疾病、腦創(chuàng)傷、器質(zhì)性精神障礙、外周血管阻塞性疾病、糖尿病神經(jīng)病變、急慢性跟腱疼痛、運動性肌肉創(chuàng)傷。 不良反應:少數(shù)病人給藥后見耳鳴、頭暈、肌束顫動、出汗腹痛等,個別病人有瞳孔縮小、嘔吐、大便增加、視力模糊、心率改變、流涎、思睡等不良反應,上述副反應的出現(xiàn)率,除惡心外均較新斯的明為低,且均可自行消失。嚴重者可用阿托品對抗。 注意事項:①禁用于心絞痛、支氣管哮喘、機械性腸梗阻病人。②慎用于妊娠婦女。
Changsha Huir Biological-tech Co.,Ltd
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