[Product name]: Dexamethasone acetate [Chemical name]: 9-fluoro-11β,17-dihydroxy-l6α-methyl-3,20-dioxopregna-1,4-dien-2l-yl acetate [Product category]:corticosteroids [CAS NO.] 1177-87-3 [molecular formula]: C24H31FO6 [molecular weight]: 434.5 [Packing specification]: 1KG/tin [specification]: CP/EP/USP/BP [Appearance]: white or almost white crystalline powder, odorless, tasted bitter [Identification]: it should be positive [Melting point]: 223℃~233℃ [specific rotation]: +82°~+88° [related substance]: max impurity ≤0.5%, total impurities≤1.0% [loss on drying]: ≤0.5% [residue on ignition]: ≤0.1% [selenium value]: ≤0.005% [absorptive index]: 343~371 [assay]: calculated the content of C24H31FO6 97on the dried basis, it should be 97.0%~102.0% [storage]: store in a airtight container, protected from light. [decription]: Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties. One possible mode of action of the anti-inflammatory properties has been documented by Dexamethasone Acetate inhibitiing upregulation of ICAM-1 (intercellular adhesion molecule-1) in cultured human mast cells. The compound also displays anti mitotic activity against chemically transformed mouse fibroblasts by halting mitosis from entering the S-phase. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.
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