Product Name: Jervine;11-Ketocyclopamine;Jerwiny;
CAS No.: 469-59-0
Synonyms: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one;(3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one; Shh Signaling Antagonist III
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one
Molecular Formula: C27H39NO3
Molecular Weight: 425.6
Appearance: White to off-white solid
Purity(HPLC):>98.0%
Biological Activity:
Inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.
Applications: Has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling.
Jervine is a steroidal alkaloid with molecular formula C27H39NO3 which is derived from the Veratrum plant genus. Similar to cyclopamine, which also occurs in the Veratrumgenus, it is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation.An alkaloid isolated from the corn lily (Veratrum californicum) is a Sonic Hedgehog gene pathway antagonist with potential anticancer properties. Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. This is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo.
關(guān)鍵字： Jervine;11-Ketocyclopamine;Jerwiny;
上海水正生物醫(yī)藥科技有限公司（Arethusa-水正生物）是一家專業(yè)從事高純度天然藥物單體的研發(fā)及銷售的科技型企業(yè)。主營業(yè)務(wù)包括中藥對照品、植物標(biāo)準(zhǔn)品、天然藥物活性單體、藥物雜質(zhì)分離純化、工藝開發(fā)研究及技術(shù)外包服務(wù)。
水正生物致力于構(gòu)建全球最有影響力的“大規(guī)模、高質(zhì)量天然產(chǎn)物庫”，為全球創(chuàng)新藥物研發(fā)機構(gòu)提供豐富的物質(zhì)基礎(chǔ)，為全產(chǎn)業(yè)發(fā)展搭建基礎(chǔ)性支撐平臺。該庫現(xiàn)已擁有3,000余種結(jié)構(gòu)類型多樣的天然化合物，幾乎涵蓋絕大部分已知的天然產(chǎn)物結(jié)構(gòu)類型，其中超過60%的產(chǎn)品無法從商業(yè)渠道獲得或現(xiàn)貨供應(yīng)商極少，它們源于650多種藥用植物或真菌（包括部分中藥），并且品種仍在持續(xù)豐富。