Product Name: Genipin
CAS No.: 6902-77-8
Synonyms: (1R,4aS,7aS)-methyl 1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate;Methyl (1R,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate;Genipin
Molecular formula: C11H14O5
Molecular Weight: 226.23
Description: White needle crystals
Solubility: soluble in DMSO, methanol, acetone and ethyl acetate, insoluble in water
Purity by HPLC≥98.0%
Biological activity:
Genipin is a compound isolated from Gardenis jasminoides Ellis fruits which acts as a cell permeable inhibitor of UCP2 (uncoupling protein 2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Genipin has been shown to induce apoptosis and is a protein cross-linking agent. Genipin, at 5 μM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.
關(guān)鍵字： Genipin;6902-77-8
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