三(2-羧乙基)膦鹽酸(TCEP.HCl)是一種非揮發(fā)性的固體。它是一種強(qiáng)還原劑。它可通過在回流的HCl水溶液中對(duì)三(2-氰基乙基)膦進(jìn)行酸水解而合成。它具有多種生物學(xué)應(yīng)用,例如多種肽和蛋白質(zhì)中二硫鍵的體內(nèi)及體外還原。1 TCEP可用作多種重金屬離子如Zn(II), Cd(II), Pb(II)以及Ni(II)的螯合劑。
TCEP Hydrochloride is a water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds. Reports indicate that TCEP Hydrochloride can rapidly reduce stable alkyl disulfides, including DTT. TCEP Hydrochloride has been observed to reduce DHA in a solution of EDTA and metaphosphoric acid, and used to conduct proteolysis and Hydrogen/Deuterium exchange. Binding studies demonstrate that TCEP Hydrochloride does not bind Hg2+, and its binding efficacy to NF-κB-DNA has been tested in vitro.Reagent for the selective reduction of disulfides in water. Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications. When basified, this water-soluble ligand allows for simple removal of ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture.
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