福司氟康唑|T5328|TargetMol

價(jià)格	￥283	￥435	￥976
包裝	5mg	10mg	25mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-02-28

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產(chǎn)品詳情

中文名稱(chēng):福司氟康唑	英文名稱(chēng):Fosfluconazole
CAS:194798-83-9	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.84%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T5328

Product Introduction

Bioactivity

名稱(chēng)	Fosfluconazole
描述	Fosfluconazole is water-soluble phosphate prodrug of fluconazole. Fluconazole is an antifungal drug.
激酶實(shí)驗(yàn)	An aliquot of 200 μl of mucosa scrap lysate solution was mixed with 100 mM phosphate buffer, pH 7.4, to a final volume at 1 ml. The concentration of the test compounds (fosphenytoin and fosfluconazole) was 10 μM. The incubation medium was prewarmed at 37°C before the reaction was initiated by addition of the tested compounds. An aliquot of 100 μl was collected from the incubation vial at the time points 0, 5, 10, 20, 30, 45, and 60 min and transferred to a 96-well plate, in which 100 μl of acetonitrile was prefilled to terminate the reaction. The samples were diluted 5-fold with acetonitrile containing 1 μM tolbutamide as an analytical internal standard. The samples were centrifuged at 4000 rpm for 5 min to precipitate protein. The supernatant was transferred to a new 96-well plate for concentration analysis by liquid chromatography/tandem mass spectrometry (LC/MS/MS) [1].
動(dòng)物實(shí)驗(yàn)	Twelve-week-old male Wistar rats (200–300 g) were used. They were housed in a temperature-controlled room and were given food and water ad libitum. All rats were anesthetized by an i.p. administration of pentobarbital (50 mg/kg body weight). A catheter was placed in the peritoneal cavity and used as an inflow drain for the dialyzing fluid. sampling. In rats receiving i.v. administration, a catheter was inserted into the left jugular vein for drug administration, and another into the right femoral artery for blood sampling. Blood samples after the i.p. administration were obtained from the heart. The rats were then allowed to recover from the anesthesia and surgery for at least 24 hr. After the 40-mL dialyzing fluid was administered intraperitoneally, FLCZ 16 mg/kg body weight) and F-FLCZ (16 mg FLCZ eq/kg body weight) were administered intravenously. The volume of the drug solution administered intravenously was 8 mL/kg. FLCZ (16 mg/kg body weight) and F-FLCZ (16 mg FLCZ eq/kg body weight) dissolved in the 40 mL of dialyzing fluid were administered intraperitoneally. The dialyzing fluid FLCZ concentration was 100 mg/L. F-FLCZ (16 mg FLCZ eq/kg body weight) was administered to ARF rats intravenously and intraperitoneally. Blood (0.5 mL) and dialyzing ‰uid (1.5 mL) samples were collected at appropriate time intervals [2].
體外活性	在Caco-2單層細(xì)胞中，10 μM Fosfluconazole在Transwell板的頂端或底部隔室中給藥。兩種前藥在頂端隔室中經(jīng)過(guò)2小時(shí)孵化后被有效裂解。ALP介導(dǎo)的轉(zhuǎn)化率隨前藥濃度呈依賴性，以Michaelis-Menten常數(shù)為標(biāo)準(zhǔn)，F(xiàn)osfluconazole在Caco-2細(xì)胞中的測(cè)定值為351μM[1]。
體內(nèi)活性	Fosfluconazole通過(guò)靜脈和腹膜內(nèi)給藥。在腹膜內(nèi)給予F-FLCZ后，F(xiàn)LCZ在循環(huán)血液和腹膜透析大鼠的透析液中被檢測(cè)到。腹膜內(nèi)給藥后血漿中FLCZ的濃度低于靜脈給藥(F-FLCZ)后的濃度[2]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 6 mg/mL (15.53 mM)
關(guān)鍵字	Fungal \| Inhibitor \| inhibit \| Fosfluconazole
相關(guān)產(chǎn)品	2-Butyl-1,2-benzisothiazolin-3-one \| Potassium gluconate \| Dehydroacetic acid sodium \| Sorbic acid \| Geraniol \| Paclobutrazol \| Veratraldehyde \| Lauryl betaine \| Methyl 2-amino-5-bromobenzoate \| Chlorobutanol hemihydrate \| Chitosan (MW 150000) \| Tebuconazole
相關(guān)庫(kù)	經(jīng)典已知活性庫(kù) \| 抗真菌庫(kù) \| 已知活性化合物庫(kù) \| ReFRAME 相關(guān)化合物庫(kù) \| 抗生素庫(kù) \| 含氟化合物庫(kù) \| NO PAINS 化合物庫(kù) \| FDA 上市藥物庫(kù) \| 藥物功能重定位化合物庫(kù) \| 人代謝物化合物庫(kù)

關(guān)鍵字：福司氟康唑|TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專(zhuān)業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫(kù)，以及多種類(lèi)型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類(lèi)多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專(zhuān)業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

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公司成立：12年
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