吡咯烷二硫代氨基甲酸銨,Pyrrolidinedithiocarbamate ammonium

吡咯烷二硫代氨基甲酸銨|T3147|TargetMol

價格	￥286	￥397	￥672
包裝	100mg	200mg	500mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:吡咯烷二硫代氨基甲酸銨	英文名稱:Pyrrolidinedithiocarbamate ammonium
CAS:5108-96-3	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: ≥98%	產(chǎn)品類別: 抑制劑
貨號: T3147

Product Introduction

Bioactivity

名稱	Pyrrolidinedithiocarbamate ammonium
描述	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
細(xì)胞實(shí)驗(yàn)	The human colon cancer cell line HT-29 is obtained and cells are grown in modified McCoy's 5A medium supplemented with 10% fetal bovine serum. To study the effect of PDTC on IL-8 production, HT-29 cells in 96-well plates are induced with 20 ng/mL of IL-1b for 18 h. Various concentrations (3-1000 mM) of PDTC or its vehicle (culture medium) are added to the cells 30 min prior to IL-1b stimulation. The concentration of IL-8 in the supernatant is determined using solid-phase enzyme-linked immunosorbent assay, as described previously employing the multiple antibody sandwich principle that specifically detects human IL-8[1].
激酶實(shí)驗(yàn)	All binding studies are performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (with v) bovine serum albumin and 0.05% (v/v) Tween-20. For the PD-l-Ig/PD-Ll-His binding assay, inhibitors are pre-incubated with PD-Ll-His (10 nM final) for 15 m in 4 μL of assay buffer, followed by addition of PD-l-Ig (20 nM final) in 1 μL of assay buffer and further incubation for 15 m. PD-L1 from either human, cyno, or mouse are used. HTRF detection is achieved using europium crypate-labeled anti- Ig (1 nM final) and allophycocyanin (APC) labeled anti-His (20 nM final). Antibodies are diluted in HTRF detection buffer and 5 μL is dispensed on top of binding reaction. The reaction mixture is allowed to equilibrate for 30 minutes and signal (665 nm/620 nm ratio) is obtained using an En Vision fluorometer. Additional binding assays are established between PD-1-Ig/PD-L2-His (20, 5 nM, respectively), CD80-His/PD-Ll-Ig (100, 10 nM, respectively) and CD80-His/CTLA4-Ig (10, 5 nM, respectively).
體外活性	細(xì)胞預(yù)處理PDTC（3-1000 mM）劑量依賴性地減少IL-8產(chǎn)生。此外，PDTC（100 mM）抑制IL-8 mRNA的積累。PDTC通過抑制NF-kB DNA結(jié)合及其依賴的轉(zhuǎn)錄活性，從而阻止NF-kB的激活。綜合我們的數(shù)據(jù)表明，通過PDTC抑制NF-kB可以降低腸上皮細(xì)胞IL-8的產(chǎn)生[1]。
體內(nèi)活性	DSS+PDTC處理的第二組表現(xiàn)出抑制小腸長度縮短和DAI得分降低。該組中活化的NF-κB水平以及IL-1β和TNF-α水平顯著低于對照組。這些發(fā)現(xiàn)表明，通過PDTC抑制NF-κB活性可以延緩由炎癥引起的粘膜組織缺陷（侵蝕或潰瘍）的愈合，但它能強(qiáng)烈抑制炎癥細(xì)胞因子（IL-1β和TNF-α）的表達(dá)，從而顯著緩解結(jié)腸炎。PDTC對于治療潰瘍性結(jié)腸炎具有重要價值[2]。
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 75 mg/mL (456.51 mM) 5% DMSO+95% Saline : 0.6 mg/mL (3.65 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
關(guān)鍵字	TNF-α \| Inhibitor \| 1-Pyrrolidinedithiocarboxylic acid ammonium \| Nuclear factor-κB \| inhibit \| NF-κB \| Pyrrolidinedithiocarbamate ammonium \| ulcerative \| inflammation \| IL-1β \| colitis \| Nuclear factor-kappaB
相關(guān)產(chǎn)品	Lidocaine hydrochloride \| sodium lauroyl-α-hydroxyethyl sulfonate \| Sodium Houttuyfonate \| Lidocaine \| 5-Aminosalicylic Acid \| Diallyl disulfide \| Glucosamine \| Sodium salicylate \| α-Lipoic Acid \| Zingerone \| Indole-3-carbinol \| Diethylmaleate
相關(guān)庫	抑制劑庫 \| 經(jīng)典已知活性庫 \| 抗癌活性化合物庫 \| 抗衰老化合物庫 \| 藥物功能重定位化合物庫 \| 抗癌藥物庫

關(guān)鍵字：吡咯烷二硫代甲酸銨|||吡咯烷二硫代氨基甲酸銨|||Pyrrolidinedithiocarbamate|||PDTC|||APDC|||Ammonium pyrrolidinedithiocarbamate|||1-Pyrrolidinedithiocarboxylic acid ammonium salt|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點(diǎn)的分子篩選到對明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

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公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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