5108-96-3
基本信息
吡咯烷二硫代氨基甲酸銨
1-吡咯烷硫代羧酸銨鹽
吡咯二硫代甲酸銨
吡咯烷二硫代甲酸銨
四次甲基二硫代氨基甲酸銨
四亞甲基二硫代氨基甲酸銨
1-吡咯烷硫代羧酸銨鹽/吡咯二硫代甲酸銨
1-吡咯烷羰基二硫酸銨鹽
吡咯烷二硫代甲酸銨鹽
1-吡咯烷硫代氨基甲酸銨鹽
1-PYRROLIDINECARBODITHIOIC ACID, AMMONIUM SALT
1-PYRROLIDINEDITHIOCARBOXYLIC ACID, AMMONIUM SALT
AMMONIUM 1-PYRROLIDINECARBODITHIOATE
AMMONIUM 1-PYRROLIDINEDITHIOCARBAMATE
AMMONIUM PYRROLIDINECARBODITHIOATE
AMMONIUM PYRROLIDINEDITHIOCARBAMATE
AMMONIUM PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT
AMMONIUM PYRROLIDINE DITHIOFORMATE
AMMONIUM PYRROLIDINE-N-DITHIOCARBAMATE
AMMONIUM PYRROLIDINO-DITHIOCARBAMATE
AMMONIUM PYRROLIDINODITHIOCARBOXYLATE
AMMONIUM TETRAMETHYLENE DITHIOCARBAMATE
APCD
APDC
APDC AMMONIUM SALT
APDTC
APDTC AMMONIUM SALT
N,N-TETRAMETHYLENEDITHIOCARBAMIC ACID AMMONIUM SALT
PDTC, NH4
物理化學性質
安全數(shù)據(jù)
應用領域
常見問題列表
Target | Value |
NF-κB
() |
Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.
The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | B23731 | 1-吡咯烷羰基二硫酸銨鹽, 98% 1-Pyrrolidinecarbodithioic acid ammonium salt, 98% | 5108-96-3 | 25g | 669元 |
2024/11/08 | B23731 | 1-吡咯烷羰基二硫酸銨鹽, 98% 1-Pyrrolidinecarbodithioic acid ammonium salt, 98% | 5108-96-3 | 100g | 1588元 |
2024/11/08 | 16205 | 1-吡咯烷羰基二硫酸銨鹽 1-Pyrrolidinecarbodithioic acid, ammonium salt, 98%, Thermo Scientific Chemicals | 5108-96-3 | 25g | 985元 |