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5108-96-3

中文名稱 吡咯烷二硫代甲酸銨鹽
英文名稱 Ammonium 1-pyrrolidinedithiocarbamate
CAS 5108-96-3
EINECS 編號 225-834-4
分子式 C5H13N3S2
MDL 編號 MFCD00012720
分子量 179.31
MOL 文件 5108-96-3.mol
更新日期 2024/12/19 09:12:55
5108-96-3 結構式 5108-96-3 結構式

基本信息

中文別名
1-吡咯烷二硫代羧酸銨鹽
吡咯烷二硫代氨基甲酸銨
1-吡咯烷硫代羧酸銨鹽
吡咯二硫代甲酸銨
吡咯烷二硫代甲酸銨
四次甲基二硫代氨基甲酸銨
四亞甲基二硫代氨基甲酸銨
1-吡咯烷硫代羧酸銨鹽/吡咯二硫代甲酸銨
1-吡咯烷羰基二硫酸銨鹽
吡咯烷二硫代甲酸銨鹽
1-吡咯烷硫代氨基甲酸銨鹽
英文別名
1-PYRROLIDINECARBODITHIOIC ACID
1-PYRROLIDINECARBODITHIOIC ACID, AMMONIUM SALT
1-PYRROLIDINEDITHIOCARBOXYLIC ACID, AMMONIUM SALT
AMMONIUM 1-PYRROLIDINECARBODITHIOATE
AMMONIUM 1-PYRROLIDINEDITHIOCARBAMATE
AMMONIUM PYRROLIDINECARBODITHIOATE
AMMONIUM PYRROLIDINEDITHIOCARBAMATE
AMMONIUM PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT
AMMONIUM PYRROLIDINE DITHIOFORMATE
AMMONIUM PYRROLIDINE-N-DITHIOCARBAMATE
AMMONIUM PYRROLIDINO-DITHIOCARBAMATE
AMMONIUM PYRROLIDINODITHIOCARBOXYLATE
AMMONIUM TETRAMETHYLENE DITHIOCARBAMATE
APCD
APDC
APDC AMMONIUM SALT
APDTC
APDTC AMMONIUM SALT
N,N-TETRAMETHYLENEDITHIOCARBAMIC ACID AMMONIUM SALT
PDTC, NH4

物理化學性質

外觀性質白色結晶性粉末。有氨氣味。有吸濕性。在空氣中不穩(wěn)定,宜保存在氨氣流中。溶于水,微溶于乙醇。熔點149-152℃。有刺激性。
熔點153-155 °C(lit.)
密度1.117 (estimate)
折射率1.5300 (estimate)
儲存條件2-8°C
溶解度190g/l
形態(tài)粉末/固體
顏色白色至灰白色
PH值6-7 (50g/l, H2O, 20℃)
水溶解性50 g/L (20 ºC)
敏感性吸濕性
BRN3730472
穩(wěn)定性穩(wěn)定的。與強氧化劑不相容。
CAS 數(shù)據(jù)庫5108-96-3(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
危險品標志Xi,Xn
危險類別碼R36/37/38-R22
安全說明S26-S36-S37/39
WGK Germany3
F3
TSCAYes
海關編碼29339990

應用領域

用途一
發(fā)射光譜測定三價鉻。多種金屬絡合劑。測尿中痕量鉛。微量測定鎘、鈷、鉍和鉬。從酸性溶液中沉淀砷、鉍、鎘、鈷、銅、鐵、錳、鎳、鉛、銻、錫、釩、鋅。原子吸收分光光度分析的絡合劑。原子吸收分析試劑

化學品安全說明書(MSDS)

常見問題列表

用途
吡咯烷二硫代甲酸銨鹽在包括金屬螯合作用在內的生物化學應用中很有用。它被用來防止一氧化氮合酶的誘導。抑制白血病HL-60細胞的凋亡也是非常重要的。
生物活性
Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt)是NF-κB的有效抑制劑,抑制IκB磷酸化、阻止NF-κB易位入核并減少下游細胞因子的表達。
靶點
TargetValue
NF-κB
()
體外研究

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.

體內研究

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.

吡咯烷二硫代甲酸銨鹽價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08B237311-吡咯烷羰基二硫酸銨鹽, 98%
1-Pyrrolidinecarbodithioic acid ammonium salt, 98%
5108-96-325g669元
2024/11/08B237311-吡咯烷羰基二硫酸銨鹽, 98%
1-Pyrrolidinecarbodithioic acid ammonium salt, 98%
5108-96-3100g1588元
2024/11/08162051-吡咯烷羰基二硫酸銨鹽
1-Pyrrolidinecarbodithioic acid, ammonium salt, 98%, Thermo Scientific Chemicals
5108-96-325g985元
"5108-96-3" 相關產(chǎn)品信息
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