Rhesus macaque IL-2 R gamma / CD132 Protein, His Tag (MALS verified)
分子別名(Synonym)
IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC
表達區(qū)間及表達系統(tǒng)(Source)
Rhesus macaque IL-2 R gamma Protein, His Tag (ILG-R52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Pro 255 (Accession # Q38JL2-1).
Predicted N-terminus: Leu 23
蛋白結構(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 29.4 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
IL-2R是一種異三聚體蛋白,與細胞因子IL-2結合并產生反應。鑒定出三條不同的IL-2R鏈,稱為α、β和γ,它們是非共價結合的。α鏈和β鏈參與結合IL-2,而細胞因子相互作用后的信號轉導由γ鏈和β亞基進行。IL-2R的α鏈可以在受體與IL-2相互作用之前與β鏈結合。單獨的γ鏈對IL-2的親和力非常弱,但在配體與α/β異二聚體結合后,γ鏈被招募到復合物中,形成非常穩(wěn)定的大分子四元配體/受體復合物。
白細胞介素-2受體亞基γ(IL2RG),也稱為細胞因子受體共同亞基γ,CD抗原CD132,gammaC,p64,屬于I型細胞因子受體家族或5型亞家族。IL2RG位于骨髓中未成熟造血細胞的表面。IL2RG缺陷是嚴重聯合免疫缺陷X連鎖T細胞陰性/B細胞陽性/NK細胞陰性(XSCID)的原因。
關鍵字: IL-2 R gamma;IL2RG蛋白;IL2RG重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。