米非司酮|T1102|TargetMol

價格	￥119	￥178	￥247
包裝	10mg	25mg	50mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:米非司酮	英文名稱:Mifepristone
CAS:84371-65-3	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: ≥95%	產(chǎn)品類別: 抑制劑
貨號: T1102

Product Introduction

Bioactivity

名稱	Mifepristone
描述	Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
細胞實驗	Cell growth is evaluated in various ovarian cancer cell lines that are subjected to dose-response or time course treatments. Media containing each of the doses of fresh steroids is replaced every 24 hours. Control groups of cells are treated with vehicle ethanol at a final concentration of less than 0.05%. Number of viable cells is evaluated by trypsinization and counting in a hemocytometer chamber using trypan blue dye exclusion. Experiments are conducted in media without phenol red and supplemented with charcoal extracted fetal bovine serum, or media containing unextracted serum and having phenol red. Similar results are obtained with both media preparations; therefore, after performing the growth curves, all subsequent experiments are conducted using media with unextracted serum and in the presence of phenol red. When indicated, the proliferation IC50s are calculated using software designed to study drug interaction. (Only for Reference)
激酶實驗	Glucocorticoid receptor (GR) antagonist activity, Progesterone receptor (PR) antagonist activity: T47D alkaline phosphatase assay: T47D human breast cancer cells are plated in 96-well tissue culture plates at 104 cells per well in assay medium [RPMI medium without phenol red containing 5% (v/v) charcoal-treated FBS and 1% (v/v) penicillin–streptomycin]. Two days later, the medium is decanted and Mifepristone or control is added at a final concentration of 0.1% (v/v) dimethylsulfoxide in fresh assay medium. Twenty-four hours later, an alkaline phosphatase assay is performed using a SEAP kit. The medium is decanted and the cells are fixed for 30 minutes at room temperature with 5% (v/v) formalin. The cells are washed once at room temperature with Hanks' buffered saline solution. Equal volumes (0.05 mL) of dilution buffer, assay buffer, and 1:20 substrate/enhancer mixture are then added. After 1-hour incubation in the dark at room temperature, the lysate is transferred to a white 96-well plate and luminescence is read using a LuminoSkan Ascen. A549 reporter assay: A549 human lung carcinoma cells are washed with OPTI-MEM I. The medium is removed and lipid–DNA complex solution (1.5 μg/mL of GRE-luciferase reporter DNA in 8.5 mL OPTI-MEM I plus 6 μL/mL DMRIE-C reagent in 8.5 mL OPTI-MEM I, combined, mixed and incubated at room temperature for 40 minutes) is overlayed onto the cells in a T160 flask. The cells are incubated for 16 hours at 37 °C in a CO2 incubator. The DNA-containing medium is removed and 30 mL of growth medium containing 5% (v/v) charcoal-treated fetal bovine serum is added. After 5-6 hours, the cells are seeded in 96-well plates and incubated overnight at 37 °C. Mifepristone is then added to each well followed by dexamethasone as a corticoid challenge. The cells are incubated for 24 hours. Luciferase assay buffer is added to each well and the cells are incubated for 30 minutes at room temperature.Luciferase activity is measured in a DYNEX Microlite plate on a TopCount.
體外活性	Mifepristone抑制人類肺癌細胞A549種皮質激素誘導的糖皮質激素反應元件偶聯(lián)的熒光素酶報告基因轉錄。而且,Mifepristone作用于人類乳腺癌細胞T47D,也阻斷孕酮對堿性磷酸酶活性的誘導作用。Mifepristone抑制卵巢癌細胞SK-OV-3 和OV2008增殖,IC50分別為6.25 μM和6.91 μM。
體內(nèi)活性	Mifepristone按最高劑量作用于大鼠,明顯減少前列腺重量,且很大程度抑制二氫睪酮引起的前列腺的生長,且誘導萎縮和細胞死亡.每天0.5 mg和1 mg Mifepristone作用于免疫抑制小鼠,可以抑制SK-OV-3腫瘤生長.
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.3 mg/mL (10.01 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 45 mg/mL (104.75 mM) Ethanol : 21.5 mg/mL (50 mM)), Heating is recommended.
關鍵字	Mifepristone \| RU38486 \| Inhibitor \| RU-38486 \| NOS \| NO Synthase \| Nitric oxide synthases \| NR3C3 \| Glucocorticoid Receptor \| Autophagy \| inhibit \| C1073 \| RU-486 \| C 1073 \| Progesterone Receptor \| RU 486
相關產(chǎn)品	Guanidine hydrochloride \| Naringin \| Valproic Acid \| Taurine \| Gefitinib \| Aceglutamide \| Hydroxychloroquine \| Curcumin \| Stavudine \| Salicylic acid \| Paeonol \| Sodium 4-phenylbutyrate
相關庫	抑制劑庫 \| 神經(jīng)保護化合物庫 \| 抗癌上市藥物庫 \| 經(jīng)典已知活性庫 \| 抗癌活性化合物庫 \| 抗衰老化合物庫 \| FDA 上市藥物庫 \| 藥物功能重定位化合物庫 \| 抗癌臨床化合物庫 \| 抗癌藥物庫

關鍵字：米非司酮|||RU486|||RU 38486|||C-1073|TargetMol

公司簡介

上海陶術生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學研究的科學家提供優(yōu)質的產(chǎn)品和專業(yè)的服務。公司下設篩選事業(yè)部，化學事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實體化合物分子供應；從商業(yè)化產(chǎn)品銷售到個性化定制合成；從對明確靶點的分子篩選到對明確分子的多靶點篩選，從高通量篩選到化學結構優(yōu)化，我們都可以滿足您的科研用品及技術服務的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領域優(yōu)秀的供應商，為超過五百家學校和各類企業(yè)提供了品質卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	化學試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務

TargetMol中國（陶術生物）

VIP 12年

公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號4樓

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米非司酮|T1102|TargetMol相關廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
米非司酮	￥15000	VIP12年	湖北威德利化學科技有限公司	2025-01-08
84371-65-3米非司酮武漢鼎信通藥業(yè) 丁亮 15871722230	￥15	VIP5年	武漢鼎信通藥業(yè)有限公司	2025-01-08
米非司酮84371-65-3	詢價	VIP4年	武漢東康源科技有限公司	2025-01-08
米非司酮	詢價	VIP4年	河北陌槿生物科技有限公司	2025-01-08
米非司酮	詢價	VIP5年	眾鑫辰實（武漢）科技有限公司	2025-01-08
米非司酮	詢價	VIP12年	深圳振強生物技術有限公司	2025-01-08
米非司酮	￥253	VIP5年	武漢鼎信通藥業(yè)有限公司	2025-01-08
米非司酮鼎信通廠家現(xiàn)貨	詢價	VIP6年	武漢鼎信通藥業(yè)有限公司	2025-01-08
米非司酮 84371-65-3 廠家生產(chǎn) 全國可發(fā) 現(xiàn)貨發(fā)售可分裝	￥26	VIP3年	湖北魏氏化學試劑股份有限公司	2025-01-08
米非司酮	詢價		沭陽羽清醫(yī)藥科技有限公司	2025-01-08

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