左旋多巴|T0848

價(jià)格	￥298	￥418
包裝	100mg	200mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:左旋多巴	英文名稱:L-DOPA
CAS:59-92-7	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.99%	產(chǎn)品類別: 抑制劑
貨號(hào): T0848

Product Introduction

Bioactivity

名稱	L-DOPA
描述	L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.
激酶實(shí)驗(yàn)	Briefly, transfected HEK-293 cells, incubated in charcoal-treated Dulbecco's modified Eagle's medium for 24 h, are washed once with Hanks' solution and resuspended in a buffer containing 100 mM NaCl, 1 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 250 mMsucrose, 20 mM Tris-HCl, pH 7.4. Cells are lysed by freezing in liquid nitrogen. Dehydrogenase activity is measured in a final volume of 20 μL containing the appropriate concentration of bile acid, 30 nCi of [3H]cortisol, and unlabeled cortisol to a final concentrations of 50 nM. The reaction is started by mixing cell lysate with the reaction mixture. Alternatively, endoplasmic reticulum microsomes are prepared from transfected HEK-293 cells and incubated with reaction mixture containing various concentrations of cortisol and CDCA. Incubation proceeded for 20 min, and the conversion of cortisol to cortisone is determined by thin layer chromatography (TLC). Because of the inaccuracy of the TLC method at low conversion rates and the end-product inhibition of 11βHSD2 at conversion rates higher than 60-70%, only conversion rates between 10 and 60% are considered for calculation. The inhibitory constant IC50 is evaluated using the curve-fitting program. Results are expressed as means±S.E. and consist of at least four independent measurements.
體外活性	L-DOPA 在誘導(dǎo)MPTP帕金森癥狀的猴子中引起多種異常運(yùn)動(dòng)的發(fā)展。L-DOPA 給藥導(dǎo)致在6-OHDA-損傷大鼠的CdPu中多巴胺D3受體表達(dá)的異位。[3] L-DOPA （50 mg/kg）通過(guò)激活完整大鼠多巴胺D1/D2受體，增加基底節(jié)區(qū)整體的內(nèi)酰胺濃度。L-DOPA 產(chǎn)生日益嚴(yán)重的口-舌自發(fā)運(yùn)動(dòng)，這些運(yùn)動(dòng)在損傷大鼠中可被大麻素激動(dòng)劑R(+)-WIN55,212-2（1 mg/kg）減緩。[4] L-DOPA 給藥逆轉(zhuǎn)了嚴(yán)重?fù)p傷大鼠中觀察到的D2多巴胺受體上調(diào)，提供了L-DOPA 在基底節(jié)達(dá)到生物活性濃度的證據(jù)。[5]
體內(nèi)活性	L-DOPA 在誘導(dǎo)MPTP帕金森癥狀的猴子中引起多種異常運(yùn)動(dòng)的發(fā)展。L-DOPA 給藥導(dǎo)致在6-OHDA-損傷大鼠的CdPu中多巴胺D3受體表達(dá)的異位。[3] L-DOPA （50 mg/kg）通過(guò)激活完整大鼠多巴胺D1/D2受體，增加基底節(jié)區(qū)整體的內(nèi)酰胺濃度。L-DOPA 產(chǎn)生日益嚴(yán)重的口-舌自發(fā)運(yùn)動(dòng)，這些運(yùn)動(dòng)在損傷大鼠中可被大麻素激動(dòng)劑R(+)-WIN55,212-2（1 mg/kg）減緩。[4] L-DOPA 給藥逆轉(zhuǎn)了嚴(yán)重?fù)p傷大鼠中觀察到的D2多巴胺受體上調(diào)，提供了L-DOPA 在基底節(jié)達(dá)到生物活性濃度的證據(jù)。[5]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : Insoluble H2O : 2.5 mM
關(guān)鍵字	blood-brain \| precursor \| Dopamine Receptor \| anti-allodynic \| inhibit \| dopamine \| L DOPA \| LDOPA \| L-DOPA \| Orally \| barrier \| neurotransmitters \| Parkinson \| Inhibitor \| Endogenous Metabolite
相關(guān)產(chǎn)品	Oleamide \| p-Hydroxybenzaldehyde \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Oxalic acid dihydrate \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid

關(guān)鍵字：左旋多巴|||Levodopa|||3,4-Dihydroxyphenylalanine|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

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公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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