Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free
分子別名(Synonym)
α-synuclein,NACP, PARK1, PARK4, PD1
表達(dá)區(qū)間及表達(dá)系統(tǒng)(Source)
Human Alpha-Synuclein Pre-formed Fibrils, Tag Free (ALN-H5115) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Predicted N-terminus: Met 1
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries no "tag".
The protein has a calculated MW of 14.5 kDa.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
運(yùn)輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C;
The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions;
The sonicated fibril should be stored at -70°C for not more than 8 weeks.
背景(Background)
α-突觸核蛋白是一種神經(jīng)元蛋白,在突觸活動中起著多種作用,如調(diào)節(jié)突觸小泡的運(yùn)輸和隨后的神經(jīng)遞質(zhì)釋放。它在多聚體膜結(jié)合狀態(tài)下也充當(dāng)分子伴侶,協(xié)助突觸前質(zhì)膜上稱為SREs(可溶性NSF附著蛋白受體)的突觸融合成分與半胱氨酸串蛋白α/DJC5結(jié)合折疊。α-突觸核蛋白的異常與帕金森病(PD)的發(fā)病機(jī)制有關(guān)。α-突觸核蛋白存在于路易體內(nèi),這是帕金森病的神經(jīng)病理學(xué)標(biāo)志,該蛋白及其聚集與最終導(dǎo)致神經(jīng)退行性變的神經(jīng)毒性途徑廣泛相關(guān)。
關(guān)鍵字: α-synuclein;α突觸核蛋白;α-synuclein蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。