Alpha-Synuclein產(chǎn)品信息
英文名稱:Alpha-synuclein
中文名稱:α-突觸核蛋白
靶點(diǎn)別稱:NACP,PARK1,PARK4
物種:Human / Mouse / Cynomolgus
屬性:Protein / Cell
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 100 mM NaAC, pH7.0 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
Alpha-Synuclein分子背景
α-突觸核蛋白是一種神經(jīng)元蛋白,在突觸活動(dòng)中起著多種作用,如調(diào)節(jié)突觸小泡的運(yùn)輸和隨后的神經(jīng)遞質(zhì)釋放。它在多聚體膜結(jié)合狀態(tài)下也充當(dāng)分子伴侶,協(xié)助突觸前質(zhì)膜上稱為SNARE(可溶性NSF附著蛋白受體)的突觸融合成分與半胱氨酸串蛋白α/DNAJC5結(jié)合折疊。α-突觸核蛋白的異常與帕金森?。?/span>PD)的發(fā)病機(jī)制有關(guān)。α-突觸核蛋白存在于路易體內(nèi),這是帕金森病的神經(jīng)病理學(xué)標(biāo)志,該蛋白及其聚集與最終導(dǎo)致神經(jīng)退行性變的神經(jīng)毒性途徑廣泛相關(guān)。
Alpha-Synuclein用戶評價(jià)
關(guān)鍵字: α突觸核蛋白;α-synuclein;Alpha-synuclein;NACP;PARK1;
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