Complement C3a產(chǎn)品信息
英文名稱(chēng):Complement Component C3a
中文名稱(chēng):補(bǔ)體C3a
靶點(diǎn)別稱(chēng):Complement C3a,C3a
物種:Human
屬性:Protein
標(biāo)記:Biotin-labeled/Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 0.2 M Arginine, PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Complement C3a分子背景
補(bǔ)體C3是血清中的主要補(bǔ)體成分。它主要由巨噬細(xì)胞和肝臟合成。C3在補(bǔ)體系統(tǒng)的激活中起著核心作用。C3轉(zhuǎn)化酶對(duì)其的處理是經(jīng)典和替代補(bǔ)體途徑的核心反應(yīng)。它被切割成兩個(gè)片段,C3a和C3b。C3a過(guò)敏毒素是局部炎癥過(guò)程的介質(zhì)。在慢性炎癥中,充當(dāng)中性粒細(xì)胞的化學(xué)引誘劑。激活后,C3b可以通過(guò)其反應(yīng)性硫酯與細(xì)胞表面碳水化合物或免疫聚集體共價(jià)結(jié)合。它誘導(dǎo)平滑肌收縮,增加血管通透性,并導(dǎo)致肥大細(xì)胞和嗜堿性白細(xì)胞釋放組胺。
關(guān)鍵字: Complement C3a;補(bǔ)體C3a;C3a蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。