Glypican 2產品信息
英文名稱:Glypican-2
中文名稱:磷脂酰肌醇蛋白2
靶點別稱:Glypican 2,GPC2
物種:Human/Mouse/Rhesus macaque
屬性:Protein
標記:Unconjugated
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Glypican 2用戶評價
Glypican 2分子背景
Glypican 2(GPC2),也稱為腦多糖,是一種在發(fā)育中的神經系統(tǒng)中發(fā)現(xiàn)的與糖磷脂酰肌醇連接的完整膜硫酸乙酰肝素蛋白多糖。腦聚糖參與細胞粘附,被認為調節(jié)軸突的生長和引導。腦聚糖對層粘連蛋白-1具有特別高的親和力。GPC2沉默使Wnt/β-catenin信號失活,并降低神經母細胞瘤發(fā)生的致癌驅動因素N-Myc的表達。靶向GPC2的免疫毒素和嵌合抗原受體(CAR)T細胞在小鼠模型中抑制神經母細胞瘤的生長。GPC3特異性抗體-藥物偶聯(lián)物(ADC)也可以抑制神經母細胞瘤細胞增殖。
關鍵字: Glypican 2;Glypican 2蛋白;Glypican 2重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。