中文名：ML133 鹽酸鹽

英文名：ML133 HCl

中文別名：(4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽

英文別名：1222781-70-5|ML133 HCL|(4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride|ML133 hydrochloride|ML 133 hydrochloride|N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride|ML133 (hydrochloride)|(4-Methoxybenzyl)(1-naphthylmethyl)amine HCl|(4-m

純度：≥98%

貨號(hào)：M129577

包裝：10mg、50mg、5mg

Cas號(hào)：1222781-70-5

存儲(chǔ)溫度：2-8°C儲(chǔ)存

產(chǎn)品介紹：

ML133 HCl是一種選擇性鉀離子通道抑制劑，作用于Kir2.1， IC50為1.8 μM (pH 7.4)和290 nM (pH 8.5)，對(duì)Kir1.1沒(méi)有作用效果，對(duì)Kir4.1和Kir7.1具有微弱的作用活性。ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

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