中文名：Tenovin-1
英文名：Tenovin-1
英文別名：Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
純度：10mM in DMSO
貨號：T408399
包裝：1ml
Cas號：380315-80-0
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2 . Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH
In?vitro
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
In?vivo
Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
Cell?Data
cell?lines：Raw 264.7 cells
Concentrations：10 μM
Incubation?Time：4 days
Powder?Purity:≥99%
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關(guān)鍵字： Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
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