Coagulation Factor III產(chǎn)品信息
英文名稱:Tissue factor
中文名稱:組織因子
靶點別稱:Coagulation Factor III,Tissue Factor,TF,F3,CD142
物種:Human/Mouse/Cynomolgus
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Coagulation Factor III用戶評價
Coagulation Factor III分子背景
全長組織因子(TF)是因子(F)VII/FVIIa的跨膜受體和輔因子。除了全長TF外,還可以產(chǎn)生另一種剪接(as)形式的TF,它缺乏跨膜結(jié)構(gòu)域,并從細(xì)胞中釋放出來。與TF相比,asTF的促凝血活性較低,因為它缺乏跨膜結(jié)構(gòu)域。組織因子由血管周圍的細(xì)胞(如外膜成纖維細(xì)胞)和體表(如上皮細(xì)胞)表達(dá),在止血中起著關(guān)鍵作用。TF也會導(dǎo)致各種形式的血栓形成。許多癌癥,特別是腺癌,表達(dá)高水平的TF。在許多類型的癌癥中,包括乳腺癌、前列腺癌、結(jié)直腸癌和胰腺癌,高水平的腫瘤TF表達(dá)與預(yù)后不良有關(guān)。
關(guān)鍵字: 組織因子;Tissue factor;Coagulation Factor I;TF蛋白;CD142;
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