IL-2產(chǎn)品信息
英文名稱:Interleukin-2
中文名稱:白細(xì)胞介素-2
靶點(diǎn)別稱:IL-2,Interleukin 2,TCGF,lymphokine
物種:Human / Mouse / Cynomolgus
屬性:Protein / Kits
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
宿主蛋白殘留(Host Cell Protein)
<0.5 ng/μg of protein tested by ELISA.
宿主核酸殘留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
無(wú)菌(Sterility)
The sterility testing was performed by membrane filtration method.
純度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
IL-2分子背景
白細(xì)胞介素-2(IL-2)是一種白介素,一種細(xì)胞因子免疫系統(tǒng)信號(hào)分子,是一種促白細(xì)胞激素,在身體對(duì)微生物感染的自然反應(yīng)中起著重要作用,并有助于區(qū)分外來(非自身)和自身。IL-2通過與淋巴細(xì)胞(負(fù)責(zé)免疫的細(xì)胞)表達(dá)的IL-2受體結(jié)合來介導(dǎo)其作用。成熟的人IL-2與小鼠和大鼠IL-2的aa序列同源性分別為56%和66%。人和小鼠IL-2具有跨物種活性。IL-2受體由三個(gè)亞基組成,它們以不同的預(yù)形成復(fù)合物存在于細(xì)胞表面。IL-2在胸腺T細(xì)胞發(fā)育過程中也是必要的,用于成熟被稱為調(diào)節(jié)性T細(xì)胞(T-reg)的獨(dú)特T細(xì)胞亞群。從胸腺中排出后,T-Regs的功能是防止其他T細(xì)胞識(shí)別和對(duì)抗“自身抗原”,這可能會(huì)導(dǎo)致“自身免疫”。T-Regs通過阻止反應(yīng)細(xì)胞產(chǎn)生IL-2來實(shí)現(xiàn)這一目的。因此,需要IL-2來區(qū)分自我和非自我,這是免疫系統(tǒng)的另一個(gè)獨(dú)特特征。
IL-2分子用戶評(píng)價(jià)
關(guān)鍵字: IL-2;IL-2蛋白;IL-2重組蛋白;白介素2;白細(xì)胞介素2;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。