中文名：甲苯磺丁脲

英文名：Tolbutamide

中文別名：甲糖寧

英文別名：NSC 23813|Orinase|Tolylsulfonylbutylurea|CAS-64-77-7|tolbutamide|U 2043|3-butyl-1-(4-methylbenzenesulfonyl)urea|DTXCID801359|N-4-Methylbenzolsulfonyl-N-butylurea|SMR000058363|Tolbutamida|Tolbutamidum [INN-Latin]|1-p-Toluenesulfonyl-3-butylurea|Diabuton|DT

純度：10mM in DMSO

貨號：T425282

包裝：1ml

Cas號：64-77-7

存儲溫度：-80℃儲存

產(chǎn)品介紹：

Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic beta-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide’s cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and glucagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.

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