中文名：替硝唑
英文名：Tinidazole
英文別名：CP12574;1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-
純度：10mM in DMSO
貨號：T407955
包裝：1ml
Cas號：19387-91-8
存儲溫度：-80℃儲存
產品介紹：
Information
Tinidazole Tinidazole (CP12574) is an anti-parasitic drug.
In?vitro
Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.
In?vivo
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
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關鍵字： CP12574;1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-
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