中文名:SR-9009,REV-ERBα/β激動(dòng)劑
英文名:SR-9009
中文別名:3-[[[(4-氯苯基)甲基-[(5-硝基噻吩-2-基)甲基]氨基]甲基]吡咯烷-1-甲酸乙酯
英文別名:SR9009|1379686-30-2|SR-9009|ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate|SR 9009|Stenabolic (SR9009)|X5DCA09N30|CHEMBL1961796|1-Pyrrolidinecarboxylic acid, 3-((((4-chlorophenyl)methyl)((5-nitro-2-th
純度:98%
貨號(hào):S275697
包裝:25mg、5mg、100mg
Cas號(hào):1379686-30-2
存儲(chǔ)溫度:避光,-20°C儲(chǔ)存,干燥
產(chǎn)品介紹:
儲(chǔ)存在-20℃。存放在干燥的條件下。該產(chǎn)品最多可存儲(chǔ)12個(gè)月。
產(chǎn)品介紹:
A pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.
SR9009 是 REV-ERBα/β 激動(dòng)劑,作用 REV-ERBα 和 REV-ERBβ 的 IC50 分別為 670 nM 和 800 nM。
查看阿拉丁官網(wǎng)此產(chǎn)品相關(guān)對(duì)應(yīng)頁(yè)面:https://www.aladdin-e.com/zh_cn/S275697.html
關(guān)鍵字: 3-[[[(4-氯苯基)甲基-[(5-硝基噻吩-2-基)甲基]氨基]甲基]吡咯烷-1-甲酸乙酯;SR9009;1379686-30-2;SR-9009
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