中文名：奧利司他

英文名：Orlistat

中文別名：奧利司他|(-)-四氫脂抑素

英文別名：orlistat|96829-58-2|Tetrahydrolipstatin|Xenical|Alli|Orlipastat|(-)-Tetrahydrolipstatin|Orlipastatum [INN-Latin]|Ro-18-0647|Ro 18-0647/002|Orlistat (Alli, Xenical)|(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate|

純度：>97.0%(HPLC)

貨號：O159936

包裝：100mg、250mg

Cas號：96829-58-2

存儲溫度：-20°C儲存,充氬

產(chǎn)品介紹：

Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies sμggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.Orlistat是一種通用的脂肪酶抑制劑，作用于人體十二指腸液的PL，IC50為122 ng/ml。

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